PAAO-YO Research:
Linda A Cernichiaro-Espinosa, MD

Dr. Linda A Cernichiaro-Espinosa, MD is a Retina and Pediatric Intraocular Tumor Specialist. She is the Founding Director of Oftalmologia Integral & RetinaKids MX. Professor at Asociación para Evitar la Ceguera en México IAP.

She recently published several articles. Below are the salient points of the articles published with links.

Traumatic retinal detachment in patients with self-injurious behavior: an international multicenter study

• 107 eyes from patients with traumatic rhegmatogenous retinal detachment (RRD) due to self injurious behavior were included from 23 international centers.
• 54% had bilateral RRD or phtisis bulbi in the fellow eye at final follow up.
• The most common systemic diagnoses related to SIB were autism spectrum disorder (35.9%), trisomy 21 (21.8%), cognitive impairment (12.8%) and cerebral palsy (12.8%).
• Primary initial surgeries were vitrectomy alone (33.3%), primary scleral buckle (SB) (25.9%) and vitrectomy with SB (39.7%), and 5 prophylactic SBs were placed. Twenty-three eyes (21.5%) with RRDs were deemed inoperable.
• The single surgery anatomic success rate (SSAS) was 23.1% without tamponade (37.2% if including silicone oil), and final reattachment was attained in 80% (36.3% without silicone oil tamponade)
• Funnel-configured RRD (P=0.006) and the presence of grade C proliferative vitreoretinopathy (P=0.002) predicted RRDs that were more likely to fail reattachment
• The use of a SB predicted final attachment rate during the initial surgery (P=0.005) or at any surgery (p=0.008; P=0.012 and 0.002, respectively, if restricting to patients with ≥12 months followup).
•   RRD from SIB poses therapeutic challenges due to limited patient cooperation, bilateral involvement, chronic RRDs, and ongoing trauma in a vulnerable and neglected patient population.
• The surgical success rates in this study were some of the lowest in the modern retinal detachment literature.
• The use of a SB may result in better outcomes, and visual function can be restored in some patients.

Rossin EJ, Tsui I, Wong SC, Hou KK, Prakhunhungsit S, Blair MP, Shapiro MJ, Leishman L, Nagiel A, Lifton JA, Quiram P, Ringeisen AL, Henderson RH, Arruti N, Buzzacco DM, Kusaka S, Ferrone PJ, Belin PJ, Chang E, Hubschman JP, Murray TG, Leung EH, Wu WC, Olsen KR, Harper CA 3rd, Rahmani S, Goldstein J, Lee T, Nudleman E, Cernichiaro-Espinosa LA, Chhablani J, Berrocal AM, Yonekawa Y. Traumatic retinal detachment in patients with self-injurious behavior: an international multicenter study. Ophthalmol Retina. 2020 Nov 22:S2468-6530(20)30463-2. doi: 10.1016/j.oret.2020.11.012. Epub ahead of print. PMID: 33238225.

Selective Pathology of Intraocular Tumors

From the MD Andserson Cancer Center, this book of Selective Pathology of Intraocular Tumors provides tools and information on the morphological approach and newest techniques in the diagnosis and treatment of malignant tumors for oncological surgeons, pathologists, oncologists and interventional radiologists. Retinoblastoma represents the most common intraocular malignant tumor in children and worldwide is the most common intraocular malignancy. Uveal melanomas are the most common malignant intraocular tumors in adults. This review chapter includes key clinical features and important histopathologic findings for diagnosis and prognosis of both entities

Chévez-Barrios P., Cernichiaro Espinosa L.A. (2020) Selective Pathology of Intraocular Tumors. In: Moran C., Kalhor N., Weissferdt A. (eds) Oncological Surgical Pathology. Springer, Cham. https://doi.org/10.1007/978-3-319-96681-6_4